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About us

The Institut Pasteur du Cambodge, a member of the Institut Pasteur International Network (IPIN), is a government-approved non-profit institution. The Institute signed an agreement with the Royal Government of Cambodia (RGC) in 1992 which was renewed by an endorsement in 2013. The Institute is under the senior patronage of the Cambodian Ministry of Health, on behalf of which it carries out life sciences and health research, public health and services as well as training activities. The Institute has reinforced this mission over the past 15 years in collaboration with national and international institutions. It contributes to the diagnosis, research, and prevention of the priority infectious diseases in Cambodia and the Greater Mekong Sub region (GMS). It plays a major role in microbiological monitoring and research in cooperation with national and international partners, as well as several IPIN institutes, first and foremost the Institut Pasteur in Paris. It hosts local researchers and international researchers from Institut Pasteur (IP), French National Research Institute for Sustainable Development (Institut de Recherche pour le Développement. IRD) and the French Agricultural Research for Development (Centre de Coopération Internationale en Recherche Agronomique Pour le Développement, CIRAD).

At the cutting edge of biomedical research in microbiology (bacteriology, virology, malaria, parasitology, mycology, immunology, epidemiology, medical entomology), its laboratories are among the most efficient in Cambodia and Southeast Asia (SEA) in the areas of diagnosis and the study of pathogen transmission, analysis of biological and genetic markers for severity or the antimicrobial resistance of microorganisms, prevention and clinical research. The significant scientific advances are published in scientific articles (and book chapters) and are made possible due to the insight and perseverance of researchers in securing contracts and carrying out research, the key involvement of the IPC’s technical and administrative personnel, support from the Cambodian MOH, critical support from the French Ministry for Higher Education, Research and Innovation (MESRI), the French Ministry for European and Foreign Affairs (MEAE), and Institut Pasteur in Paris.

IPC is intensely involved in university-level training. Students in biology, biomedical sciences, engineering, master’s and doctoral students from different universities in Cambodia, France and other countries were hosted by IPC. In 2019, in total 17 graduate students had long term training (from several weeks up to 36 months) at IPC (13 Cambodian students, 4 foreign students). IPC strategy focuses on the promotion of careers for young Cambodian scientists by providing them with a competitive, world-class scientific environment.  Memoranda of Understanding have been signed with UHS, ITC and renewed with Calmette Hospital. Relationships with RUA, RUPP, and Puthisastra University were reinforced in 2019.

The  IPC has a staff of over 255 comprising 14 nationalities, including eight local senior scientists, two expatriates at the senior management level (one international technical expert from MEAE and one from IP), ten expatriate scientists (eight from IP, one CIRAD and one IRD), two research engineers from IRD and three from IPC, five PhD students and five post-doctorates.

IPC is composed of an administrative and financial department, several services (medical biology laboratory, laboratory for environment and food safety (LEFS), vaccine center, three rabies preventiion centers, five research units: immunology, medical and veterinary entomology, virology, malaria, and epidemiology/public health including a team dedicated to clinical research.

IPC's Director

Dr. Laurence BARIL

The Institut Pasteur du Cambodge (IPC), established in 1953, is a research institution operating under the auspice of the Cambodian Ministry of Health (MoH) and the Institut Pasteur in Paris (France). IPC missions are to conduct innovative health research on infectious and emerging diseases in Cambodia, to provide vaccination and medical biology services, and to contribute to the training of medical doctors, pharmacists, veterinarians, engineers, masters and PhD in biological sciences in Cambodia and internationally. The staff is around 250 people including local and international researchers.

IPC focuses its research and public health activities to control communicable diseases in partnership with hospitals, specialized Cambodian centers from MoH (CDC, NIPH, CENAT, NCHADS, CNM,…), the Ministry of Agriculture, Forestry and Fishery, and the main universities in Cambodia (UHS, ITC, RUPP, RUA, UP…). IPC welcomes students and fellows from Cambodia and from all around the world.

There are key needs for high quality and innovative research on rabies, tuberculosis, HIV, hepatitis, dengue fever and other vector-borne diseases, emerging viruses, which continue to drive high morbidity and mortality in Cambodia. In addition, the fight against bacterial infections is compromised by the increase in antibiotic resistance. If malaria is declining, drug-resistant parasites are present. All those topics require that IPC continue to develop its research and activities to serve the population living in Cambodia.

IPC hosts several reference laboratories for a number of pathogens (Influenza, Rabies, dengue, COVID-19 …); several programs are in place to identify, diagnose, and sequence numerous other emerging pathogens including zoonotic diseases. In response to the need for a bio-safe and bio-secured facility to handle biological samples from dangerous and/or unknown pathogens, IPC was equipped with the first and only BSL-3 laboratory in Cambodia in 2008.

The COVID-19 pandemic illustrates well the importance of IPC at national, regional and international level. As of January 2020, on request of the Cambodian MoH, using our BLS-3-level capacity together with diagnostic test development, IPC has implemented, validated, and ensured diagnostic capacity to identify COVID-19 cases in Cambodia. IPC has also supported the Cambodian CDC in charge of the national response coordination for COVID-19 with its competencies in data management system and epidemiology. Therefore, from January to May 2020, IPC was the only laboratory for COVID-19 diagnosis and identification in Cambodia. Since June 2020, NIPH is actively contributing to this COVID-19 diagnostic effort and other laboratories should be equipped before the end of 2020.

The Virology Unit has also successfully cultured and sequenced the virus (SARS-CoV-2) from clinical samples of infected patients. This will contribute to the global efforts in diagnosis, vaccine and drug development against COVID-19. In April 2020, the World Health Organization (WHO) has named IPC as one of COVID-19 Global Reference Laboratory. The WHO COVID-19 Reference Laboratory Network is comprised of laboratories able to provide confirmatory testing for COVID-19 and to accelerate new technology (testing and equipment) validation such as vaccines and drugs as they are becoming available. It is an important recognition for IPC and for Cambodia.

We would like to thank the Royal Government of Cambodia, WHO, national and international development partners, private donors for their trust and support to IPC in the fight against COVID-19. Those financial supports help IPC to face the multiple challenges due to this sanitary crisis and to support the Cambodian MoH on a daily basis. It is now necessary to combine diagnostic and surveillance efforts to research efforts against this new virus, its transmission modes and the immune response in human. This is achievable only through high excellence scientific collaborations. It is also necessary to be well prepared for the next new pathogen emergencies and to continue the high excellence research for the other known pathogens.

The IPC staff, aware of the challenges and its responsibilities, is fully committed, with its partners and the International Pasteur Institutes Network (IPIN), sharing its values for innovation, solidarity, passion, responsibility and multiculturalism, to understand and combat infectious diseases in order to enable all Cambodians to benefit from the best possible well-being.

L’institut Pasteur du Cambodge (IPC), établit en 1953, est une institution de recherche sous tutelle du Ministère cambodgien de la Santé et de l’Institut Pasteur à Paris (France). L’IPC a pour mission de réaliser des recherches innovantes en santé concernant les maladies infectieuses et émergentes mais aussi d’offrir des services de vaccination et de biologie médicale, ainsi que de contribuer à la formation des médecins, pharmaciens, vétérinaires, ingénieurs, masters et docteurs en sciences biologiques du Cambodge et internationalement. Environ 250 personnes travaillent à l’IPC y compris des scientifiques locaux et internationaux.

L’IPC réalise ses activités de recherche et de santé publique pour la lutte contre les maladies transmissibles en partenariat avec les hôpitaux, les centres cambodgiens spécialisés du Ministère de la Santé (CDC, NIPH, CENAT, NCHADS, CNM, …), du Ministère de l’agriculture, Forêt et Pêche, et des principales universités du Cambodge (USS, ITC, URPP, URA, UP …). L’IPC accueille des étudiants et des stagiaires du Cambodge et du monde entier.

Les besoins pour une recherche innovante de qualité sont importants contre la rage, la tuberculose, le VIH, les hépatites, la dengue et les autres maladies vectorielles, les virus émergents qui continuent d’entrainer une forte morbidité et mortalité au Cambodge. De plus, la lutte contre les infections bactériennes est compromise par l’augmentation de la résistance aux antibiotiques. Si le paludisme est en régression, les parasites résistant aux traitements sont présents. Tous ces aspects nécessitent que l’IPC continue de développer ses recherches et ses activités au service de la population du Cambodge.

L’IPC héberge plusieurs laboratoires de référence pour un certain nombre d’agents pathogènes (grippe, rage, dengue, COVID-19 …) ; de nombreux programmes sont en place afin d’identifier, diagnostiquer et séquencer les agents pathogènes émergents y compris les zoonoses. En réponse aux besoins de bio-sûreté et de biosécurité afin de traiter les échantillons biologiques dangereux et/ou lorsque le pathogène n’est pas encore connu, IPC a été équipé du seul laboratoire de haute sécurité (BSL-3) du Cambodge en 2008.

La pandémie de COVID-19 illustre bien l’importance de l’IPC au niveau national, régional et international. Dès Janvier 2020, à la demande du Ministère de la Santé, en utilisant notre capacité de niveau BLS-3 conjointement au développement de tests diagnostiques, l’IPC a mis en œuvre, validé et assuré l’identification des cas de COVID-19 au Cambodge. L’IPC a également appuyé le CDC cambodgien qui coordonne la réponse au niveau national contre COVID-19 avec ses compétences en gestion de données et en épidémiologie. Ainsi, de Janvier 2020 à Mai 2020, l’IPC a été le seul laboratoire de diagnostic et d’identification du COVID-19 au Cambodge. Depuis Juin 2020, le NIPH contribue activement à cet effort national de diagnostic de la COVID-19 et d’autres laboratoires devraient être équipés d’ici fin 2020.

L’unité de virologie a aussi réussi à cultiver et séquencer le virus (SARS-CoV-2) à partir d’échantillons cliniques de patients infectés. Ceci contribuera aux efforts mondiaux de diagnostic et de développement de vaccins et de médicaments contre la COVID-19. En avril 2020, l’Organisation Mondiale de la Santé (OMS) a nommé l’IPC comme un des Laboratoires Global de Référence pour la COVID-19. Le réseau de l’OMS de Laboratoires de Référence pour la COVID-19 est composé de laboratoires capables de fournir des tests de confirmation pour COVID-19 et d’accélérer la validation de nouvelles techniques (tests ou équipement) et des vaccins et traitements spécifiques lorsqu’ils seront accessibles. C’est une reconnaissance importante pour IPC et pour le Cambodge.

Nous tenons à remercier le Gouvernement Royal du Cambodge, l’OMS, les partenaires nationaux et internationaux du développement, les donateurs privés pour leur confiance et leur soutien à l’IPC dans la lutte contre la COVID-19. Ces soutiens financiers ont permis à l’IPC de faire face aux multiples obstacles créés par cette crise sanitaire et d’appuyer quotidiennement le Ministère de la Santé. Il est maintenant nécessaire de combiner les efforts de diagnostic et de surveillance à des efforts de recherche sur ce nouveau virus, ses modes de propagation et la réponse immune chez l’homme. Ceci n’est possible que dans le cadre de collaborations scientifiques d’excellence. Il s’agit bien sûr d’être mieux préparer pour les prochaines émergences de nouveaux pathogènes et de continuer une recherche d’excellence sur les autres pathogènes connus.

Le personnel de l’IPC, conscient des enjeux et de ses responsabilités, s’investit totalement, avec ses partenaires et le Réseau International des Instituts Pasteur (RIIP), dont il partage les valeurs d’innovation, de solidarité, de passion, de responsabilité, de multiculturalisme afin de comprendre et combattre les maladies infectieuses et permettre à tous les cambodgiens de bénéficier du meilleur bien-être possible.

History

December 1953 IPC History
January 1958 IPC History
1975-1979 IPC History
1986-1994 IPC History
August, 1992 IPC History
March, 1994 IPC History
February, 1995 IPC History
February, 1995 IPC History
February, 1995 IPC History

History

December 1953 IPC History
January 1958 IPC History
1975-1979 IPC History
1986-1994 IPC History
August, 1992 IPC History
March, 1994 IPC History
February, 1995 IPC History
February, 1995 IPC History
February, 1995 IPC History

IPC Governance

Scientific activities of Institut Pasteur du Cambodge are followed by a Scientific advisory board constituted of 7 members.

The role of the Scientific advisory board (= scientific council) is to give advice to researchers and to the IPC director on scientific and training activities conducted at IPC, on research and capacity building projects, on challenges, collaborations, opportunities, etc. .

In 2018 the members of the board were:

Two (2) International Scientists 

    • Dr. Anne Laure BANULS, PhD, HDR, DR2, IRD/Montpellier – France.
    • Dr. Wai-Hong THAM, Associate Professor, malaria, The Walter + Eliza Hall Institute, Melbourne, Australia

Three (3) Cambodian Scientists :

    • Pr. SAPHONN Vonthanak, PhD, Rector UHS (Université des Sciences de la Santé).
    • H.E Dr. TOUCH Visalsok, Phd Biology, Secretary of State, Ministry of Education, Youth and Sport (MoEYS), Cambodia.
    • Dr. YI Siyan, Director of Khana, Cambodia, and Senior Research Fellow, Saw Swee Hock School of Public Health, NUS, Singapore

Two (2) scientists representative of Institut Pasteur Paris

    • Dr. Monique LAFON, PhD, HDR, DRIP Paris.
    • Dr Simon CAUCHEMEZ, PhD, HDR, IP Paris

The SAB meets every 18 months. Members of SAB must be replaced every 3 sessions.

Last meeting was on 06 and 07th of December 2018.

Previous meeting were in June 2017, November 2015, November 2012 and in April 2014.

Activities and financial matters of the Pasteur Institute du Cambodge are reviewed by a yearly Liaison Council of 10 members, chaired by HE the Minister of Health of the Kingdom of Cambodia, in the presence of HE the Ambassador of France, the President of Institut Pasteur (Paris) and representatives of several national authorities (Ministries of Finances, Ministry of Agriculture and Fisheries and Ministry of Education, Youth and Sports) and international agencies (WHO, UNICEF, etc.)

The Liaison Council reviews and approves the annual report presented to it by the Director of the IPC. It reviews the program of activities of the Pasteur Institute du Cambodge for the coming fiscal year.

The Liaison Council may invite to its meetings, in an advisory capacity, personalities whose assistance would be useful for the work of the Council.

Board members:

PRESIDENT :

His Excellency Professor Mam Bunheng, Minister of Health

PERMANENT MEMBERS:

      • HE the Minister of Education, Youth and Sports,
      • Mr. the Secretary of State for Health, Ministry of Health,
      • HE the Ambassador of France in Cambodia,
      • Mr. the President – Director General of Institut Pasteur (Paris),
      • Mr. the representative of HE the Minister of the Economy and Finance
      • Ms. the Vice-Rector for International Relations, Royal University of Agriculture,
      • Mr. the Rector of the University of Health Sciences,
      • Mr. the WHO Representative in Cambodia.
      • Ms. or Mr. Regional Representative of UNICEF in Cambodia

INVITED MEMBERS:

      • Mr. Director, Institut Pasteur du Cambodge
      • Madam Director General of Health, Ministry of Health
      • Mr. Director, National Center for Malaria Control, Parasitology and Entomology (CNM)
      • Mr. Director, National Center of Tuberculosis Control (CENAT)
      • Mr. Director, Director, National Center for HIV / AIDS, Dermatology and STD (NCHADS)
      • Mr. Director, National Institute of Public Health (NIPH)
      • Mr. Director, National Institute of Veterinary Research (NaVRI)
      • Mr. the Director, Ministry of Health, CDC, Department of the Fight against Communicable Diseases
      • Mr. the Scientific Director, NAMRU-2
      • Ms. the Director, French Development Agency (AFD)
      • Mr. the Director, Calmette Hospital Mr. Director, National Pediatric Hospital
      • Mr. President, Beat Richner Foundation, Kantha Bopha Hospital
      • Mr. or Ms. Director, US-CDC
      • Ms. or Mr. Director, UNAIDS Country Coordinator, Cambodia
      • Ms. or Mr. Cooperation and Cultural Action, French Embassy in Cambodia
      • Ms. or Mr. Director, Office of Public Health and Education USAID / Cambodia
      • Mr. Deputy Director, Institut Pasteur du Cambodge
      • Mr. Director of Administration and Finance, Institut Pasteur du Cambodge

The last council was held in May 2020 under the presidency of His Excellency Professor Mam Bunheng, Minister of Health. Due to the COVID-19 pandemic, the Liaison Council had to take place through video conference.

The next council will take place in spring 2021

The Institut Pasteur du Cambodge is proudly member of the Institut Pasteur International Network (IPIN).

The 32 member institutes, partners and associates in scientific research, public health services and education alliances, join the Network on a voluntary basis. These institutes have signed the Institut Pasteur International Network Cooperation Agreement. A charter of Pasteurian values has therefore been adopted by all members of the network.

Present on five continents, researchers from the Institut Pasteur International Network — women and men from many different cultural backgrounds — are united by the same Pasteurian culture, scientific rigor and values.

The Council of Directors of the International Network decides on which institutes can join the network. It is made up of the Director of each member institute and chaired by the Institut Pasteur’s President. It meets once or twice a year and elects twelve representatives at the Institut Pasteur’s General Meeting. When they meet, the Directors draw up and approve the main areas of development for the International Network and the conditions of application.

The Pasteur International Network Association, set up in 2011 under the 1901 French law, is the legal entity of the Institut Pasteur International Network. International Network institutes make up its membership. Chaired by the Institut Pasteur via its President, this Association has two governing bodies:

      • a General Meeting, bringing together all member institutes,
      • a Board of Directors, featuring 12 members: five representatives from member institutes, elected by region (Africa-Indian Ocean, the Americas, Asia-Pacific, Europe, North Africa-Iran), five representatives from the Institut Pasteur and two external co-opted members.

On this basis, it manages the International courses (around 15 courses a year, put on in Network institutes), organizes Regional Meetings — to foster links between researchers —, and sets up new scientific projects for international cooperation. In addition, it develops several initiatives to promote the role and raise the profile of the Network in terms of health research worldwide.

In this capacity, it was recognized as an organization in “Official Relations” with the World Health Organization in 2016, highlighting the role of the Institut Pasteur International Network in global public health.

The Department of International Affairs is tighly associated with the coordination of joint activities and participation in the board of directors’ and scientific council meetings of International Network member institutes. It also oversees funding and the secondment of staff to certain institutes from the Institut Pasteur in Paris, with the backing of the French Ministry of Foreign Affairs and International Development and the Ministry for Higher Education and Research.

Charter of Pasteurian Values (2004)

The Members, Corresponding Institutions and Partners to the Institut Pasteur International Network are committed to respecting the following basic principles essential in continuing the work originally undertaken by Louis Pasteur, including:

      • Acting responsibly and in a spirit of solidarity for the general good at all times, and continuing to work in the universal, generous and humanist spirit of the work originally undertaken by Louis Pasteur.
      • Making active contribution to public health, always striving to sustain it through research and innovation.
      • Abiding by the ethical principles inherent to research and applications thereof, in particular, integrity when carrying out scientific research and probity in relations between researchers.
      • Showing rigor, devotion and efficiency in investigating, diagnosing and conducting early response to new epidemics and emerging pathologies.
      • Developing freedom of initiative and critical thinking in researchers, by involving them in determining the research avenues which they intend to pursue further to their institution’s strategic objectives.
      • Maintaining excellence in research by regularly assessing researchers and the relevance of research programs, and through appropriate training.
      • Developing training and continuing education, particularly for the benefit of researchers from countries where Network Institutes are based, spreading knowledge, and ensuring open access to knowledge.
      • Fostering access to innovation and possible use thereof, paying particular attention to the most disadvantaged countries.
      • Respecting the environment, maintaining peaceful objectives for research and taking action in line with sustainable development principles.
      • Taking action in line with the laws and regulations in effect, abiding by the principles of transparency and non-corruption.
      • Abiding by the principles of neutrality and reserve in the event of civil, armed and other conflicts.

Facilities

Institut Pasteur du Cambodge has developed technologies for the diagnosis of infectious diseases, incorporating special care in the standardization of techniques through ongoing external quality controls.

This know-how is based on qualified employees and efficient infrastructure. The modern equipment installed in modern and secure laboratories ensures the best quality of analysis and their results. This professional environment applies to Biomedical Analysis as well as research activities on the study of micro-organisms pathogenic to humans: bacteria (tuberculosis, cholera, melioidosis, enteropathogenic bacteria, leptospirosis …), fungi (candidiasis, aspergillosis, cryptococcosis …), viruses (HIV, influenza, respiratory viruses, dengue, Japanese encephalitis, Chikungunya, EV71 and other enteroviruses, hantavirus, rabies …), parasites (malaria …)

The Institut Pasteur du Cambodge owns five laboratories type P2 and 2 laboratories P2 + necessary for handling hazardous microorganisms but not fatal for humans or for which vaccines and treatments exists: tuberculosis, rabies, respiratory viruses classics etc.. Laboratories are placed in depression zone and entrance is through an airlock. Pathogens are handled in vertical laminar flow hoods to protect the operator.

IPC has largely improved its equipments for research and public health programs, thanks to grant supports with collaborative institutions and the support of Institut Pasteur in Paris.

      1. IPC uses the BSL-3 laboratory for service and research purposes (four modules occupied for MDR- and XDR-TB, H5N1 Avian flu, new or unknown viruses isolated from severe human cases, and one ASL-3 animal facility for research projects on virus transmission and pathophysiology experiments. There are very few such laboratories in Southeast Asia.
      2. A renewed Immunology Platform provides expertise on cellular immune responses to infections, with emphasis on NK cell activation during HIV, HIV/TB, and dengue infections. The platform is equipped with FACScalibur and F500 flow cytometer.
      3. IPC has renovated and expanded its animal facility and has built up an insectary in 2011.
      4. The capacity of molecular biology has been recently improved with new equipments:  GeneXpert for TB, LAMP for malaria and TB; Luminex, 454 High-throughput sequencing.
      5. The Malaria Molecular Epidemiology Unit has acquired a mobile laboratory for on-site blood sample analysis in remote areas of Cambodia.
      6. A regional platform (PR-Asia) for research on transmissible infection and emerging pathogens (founded by INSERM, ANRS, IRD, Fondation Mérieux and Institut Pasteur) build up in 2013 to provide laboratories for researchers working on transversal projects with IPC.

The quality of medical analysis and biomedical research programs are based on a variety of high-tech equipment to study biological, microbiological, genetic and pathophysiological infectious diseases, and on staff with a good knowledge on the pathogens studied. Infrastructure and safety of this technology platform are controlled by an engineer on hygiene, safety, quality and metrology. Maintenance of the platform is provided by technicians and engineers specializing in laboratory equipment (platform itself is under continuous maintenance by companies) and used by competent researchers and trained professionals. The technical platform is open to other organizations for training and research programs in collaboration with our teams.

Main Nacional Partners

Main International Partners

OPEN HOURS
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